性欲亢进BDI患者加工色情时皮层/外周反应与性梦经历和人格的关联

Hypersexuality in bipolar disorder type I (BD I) creates negative effects on patients themselves, their families and the society. Patients’ behaviors are influenced by their own affective states, sexual dream experiences and personality traits, and by the external erotic stimulation as well. However, when these patients are processing external emotions, it remains unclear how the brain cognitive and peripheral physiological changes, and their associations with sexual dream experiences and personality traits would be. We hypothesize that when processing erotic emotion, these patients display cerebral focal and connectivity abnormalities as expressed in the event-related potentials and functional magnetic resonance imaging and the peripheral multiple physiological responses, and these abnormalities are associated with patients own sexual dream experiences and some personality traits. We would like to enroll 50 BD I patients with hypersexuality, 50 BD I without hypersexuality, and 50 Cluster B personality disorders without hypersexuality, and 150 healthy volunteers. We will invite these participants, during their waking-state, to report their own affective states, sexual dream experiences, and personality traits, and to undergo tests of ERPs, fMRI and multiple physiological measures in response to erotica and other emotional stimuli. We will look for the characteristics of the central and peripheral functions, and their relationships with the sexual dream experiences and personality traits in these target patients. The possible results would contribute to the explanations for abnormal cognition and behavior in bipolar disorder, and to the familial and social stabilities.

性欲亢进的双相情感障碍I型(BDI)患者对自身及家庭社会均有负面作用，其行为受到自身情感状态、性梦经历和人格的影响，也受到外在色情刺激的影响，然而在加工外在情绪时，其脑部认知和外周生理指标状态及其与性梦经历和人格特质的关联均不明朗。我们假设在清醒状态加工色情情绪时，这类患者事件相关电位和功能磁共振所示的脑区激活和连接模式及外周多导生理指标均异常，且与其离奇性梦经历和某些人格障碍特质有关。我们打算在性欲亢进BDI患者(50名)，无性欲亢进BDI患者(50名)，无性欲亢进B簇人格障碍患者(50名)和健康志愿者(150名)身上采集其情感状态，性梦经历，人格特质，并通过以色情及其他情绪刺激来采集其脑部事件相关电位、功能磁共振和外周多导生理指标，以期找出目标患者在情绪加工中中枢与外周功能特点及其与性梦经历和人格特质的关联。相关数据对双相情感障碍的认知行为病理解释及家庭和社会的稳定将产生积极意义。

性欲亢进的双相情感障碍I型 (BDI) 患者对自身及家庭社会均有负面作用，其行为受到自身情感状态、性梦经历和人格的影响，也受到外在色情刺激的影响，然而在加工外在情绪时，其脑部认知和外周生理指标状态及其与性梦经历和人格特质的关联均不明朗。我们假设在清醒状态加工色情情绪时，这类患者事件相关电位和功能磁共振所示的脑区激活和连接模式及外周多导生理指标均异常，且与其离奇性梦经历和某些人格障碍特质有关。因此我们测量了性欲亢进BDI患者，无性欲亢进BDI患者，无性欲亢进B簇人格障碍患者和健康志愿者的情感状态，性梦经历，人格特质，并通过以色情及其他情绪刺激来采集其脑部事件相关电位、功能磁共振和外周多导生理指标，结果发现性欲亢进BDI患者有着明显的情绪改变，性梦经历，大多数障碍人格特质上得分更高，也发现了其在情绪加工和调控，尤其面对色情情绪时，中枢和外周功能存在特异性改变。相关数据对双相情感障碍的认知行为病理解释及家庭和社会的稳定将产生积极意义。