环境胁迫对成年雄性麝鼠能量代谢和繁殖功能的影响

The muskrat is the amphibious rodents. The muskiness that secreted by the adult male muskrat is similar to the natural ones, which have the high medical value. The environmental stress, including the food, temperature,photoperiod and water, would take the great effects on the energy metablism, reproductive function and the secretion of the muskiness in adult male muskrat. This program aims to explore the center mechanism that regulate the energy metablism and reproductive function of the muskrat under environmental stress. We want to find the optimum treatment to promote the secretion of the muskiness in adult male muskrat.

麝鼠是一类水陆两栖的啮齿动物。成年雄性麝鼠分泌的麝香与天然麝香成分接近，具有很高医学价值。环境中的食物、温度、光周期和水分等胁迫因子将对雄性麝鼠的能量代谢、繁殖和麝香的分泌产生重要影响。本项目旨在探讨食物、温度、光周期和水分等环境胁迫因子对水陆两栖麝鼠的能量代谢和繁殖功能影响的中枢调控机理，寻求提高成年雄性麝鼠分泌麝香的最佳途径。

本研究开展了食物、光周期的驯化处理对成年雄性麝鼠能量代谢和繁殖功能影响的研究。规则的限食处理能够明显增加成年雄性麝鼠的麝香的日平均分泌量，但是明显降低了成年雄性麝鼠的能量代谢效应。光周期的研究表明雄性麝鼠下丘脑的 GnRH 神经元代谢的调节与Kiss-1系统神经肽的表达有关。这表明水陆两栖的成年雄性麝鼠在适当的能量胁迫环境适应中将会优先选择繁殖功能的增强，部分地抑制生存的适应效应。这种环境适应的神经调控机理与环境胁迫因子激活 HPA轴 与HPG轴间的协同调节有关。