基于离子液体微阵列的单分子层荧光薄膜构建及其气相传感应用

Spin-coating of fluorescent polymers, physical entrapment of fluorescent probe in a porous matrix and chemical monolayer assembly of fluorophore on a substrate are the most common approaches for the fabrication of fluorescent sensing films. Up to now, various of fluorescent sensing films with excellent sensing performance have been developed by employing these methods. However, their applications met a tough challenge for their inherent limitations such as the poor diffusion of the analytes within films, the photodecomposition of fluorophores on a gas-solid interface etc. Therefore, it is urgent and significant to develop new strategies for fabricating new type of fluorescent sensing films. Based on our previous research work, a series of novel amphiphilic BODIPY derivatives will be synthesized; The self-assembly properties and mechanism of the obtained amphiphiles will be studied. The fluorescent monolayer films supported by ionic liquid microarrays will be constructed; The sensing performance of the monolayer film to various gases will evaluated. The dependence of the sensing performance on the structure of the monolayer film and the physicochemical properties of the medium will be examined; The sensing mechanism of the fluorescent monolayer film will be investigated by different techniques. It is believed that these kinds of studies will be favorable for broadening the design strategy, enriching the research content, overcoming the limitations and boosting the development of fluorescent sensing films, and lay foundations for fabricating new efficient gas sensing platform.

物理旋涂，多孔基质包载和化学单层组装是荧光薄膜传感材料创制的主要途径，但业已报道的传感薄膜存在气体分子通透性较差、光照下气固界面上荧光物种易降解等问题而限制了其实际应用。因此，发展新的荧光薄膜材料创制策略有着重要的学术和实践意义。为此，本项目拟立足已有工作基础，设计合成多个系列结构新颖的两亲性BODIPY衍生物；研究所得化合物在难挥发离子液体中的自组装性能和机理；构建离子液体微阵列担载的单分子层荧光传感薄膜；考察传感薄膜对相关气体分子的传感性能；研究传感性能对薄膜微观结构及组装介质性能的依赖性；揭示传感薄膜对相关气体分子的传感机理。相信通过构建基于离子液体微阵列的单分子层荧光薄膜，考察其光物理性质和传感特性，研究与之相关的基本科学问题，必将有助于拓展荧光传感薄膜设计思路，丰富荧光传感薄膜研究内容，克服现有荧光传感薄膜存在问题，提升荧光传感薄膜创制水平，为新颖高效气相传感平台搭建奠定基础。

薄膜基荧光传感是业界公认的最具发展潜力的新一代微痕量物质探测技术，然而，固体基质担载的荧光薄膜仍存在着气体分子通透性较差、光照下气固界面上荧光物种易降解等问题而限制了其实际应用。因此，发展新的荧光薄膜材料创制策略必然有着重要的学术和实践意义。在自然科学基金的支持下，项目组依据计划书所规定的研究任务，围绕两亲性BODIPY衍生物和两亲性铂配合物的设计合成，微阵列化气-液界面单分子层荧光薄膜的构建以及对VOCs气体的传感识别展开研究工作。过去四年里，项目组设计合成了9种两亲性BODIPY衍生物、2种两亲性铂配合物、1种两亲性芘衍生物、1种两亲性萘衍生物、1种两亲性香豆素衍生物和1种两亲性罗丹明衍生物，发展了可大幅提升荧光物种光化学稳定性的有效制膜方法，构建了8种微阵列化的气-液界面单分子层荧光薄膜，实现了对气相甲醛、苯胺、硝基苯、神经毒气模拟物、对映异构体等分子的高选择性、高灵敏度、快速识别，而且荧光薄膜的传感性能明显优于相应基质包载薄膜。此外，项目组还成功制备了包含多个传感微区的阵列传感器，实现了对多种VOCs气体的模式识别，该项目的顺利开展拓展了荧光传感薄膜设计思路，提升了荧光薄膜的传感性能，为新颖高效气相传感平台搭建奠定了基础。