钒对大鼠学习记忆的影响及可能机制研究

Learning and memory is one of the important function of the nervous system. At present, the cause of death and disability of neurodegeneration proportion is 4% and 5%， respectively. Learning and memory function decline seriously. The causes are complex. Studies have shown that occupational and environmental factors (Such as heavy metal, organic solvents, wood preservatives and pesticides contact) may have contributed to neurodegenerative diseases and threat to human health seriously. Due to the rapid development of vanadium industry at present, whether exposure to vanadium would affect learning and memory function and its possible mechanism has not been elucidated. . On the basis of epidemiological investigation and preliminary experiment, our project plans to observe the effect of learning and memory function through animal model exposure to different doses of vanadium . We plan to perform molecular biology tests to detect the expression of genes involved in cell apoptosis, oxidative damage and the respect of learning and memory in brain hippocampus and striatum, and further probe the possible mechanism of vanadium induced the impairment of learning and memory function. Our project will be conductive to provide a scientific basis for setting the occupational health standards for vanadium occupational exposures, and prevent and treat the damage to the nervous system in the vanadium occupational exposures .

学习记忆是神经系统重要功能之一，目前，神经退行性病变引起死亡与残疾比例分别为4%与5%，并有上升趋势，学习记忆功能严重下降，其病因复杂，有研究表明职业及环境因素（如重金属、有机溶剂、木材防腐剂、农药等）可能是导致神经退行性疾病的病因之一，对人类健康造成了极大威胁，目前由于钒产业的迅速发展，环境钒暴露对机体学习记忆的影响机制尚不明确。. 本项目拟通过动物实验，在前期人群流行病学调查及初步动物学实验的基础上，观察不同剂量的钒通过呼吸道暴露对大鼠学习记忆功能的影响; 运用分子生物学手段，检测脑组织海马及纹状体在细胞凋亡、氧化损伤、学习记忆等方面的相关基因表达及神经递质的检测，探索职业环境钒暴露影响学习记忆功能的可能机制，为钒对职业暴露人群神经系统的损害制定更完善的职业卫生标准及防治钒暴露对机体神经系统的损害提供科学依据。