三维石墨烯-多元金属纳米晶介孔有序电化学传感界面的受控组装及应用

High sensitivity and selectivity are the key issues in electrochemical sensors. The construction of electrochemical interface with high catalytic activity, large specific surface, sound biocompatibility, and excellent conductivity is the key step to enhance the performance of novel electrochemical sensors. This proposal is aimed to design and optimize the three-dimensional graphene loaded nanoalloy electrochemical interface on the base of their synergetic effects and coupling characteristic. The main points are summarized as the following. 1st, low dimensional nanoalloys: study on their water solution synthesis and electrocatalytic activity; 2nd, construction of the ordered electrochemical interface via the coupling between three-dimensional graphene and mesoporous nanoalloys. 3rd, synergetically fingering molecules by the multi-catalytic center alloys. 4th, designing electrochemical immunoassay on the base of 3D graphene-nanoalloy composite for the detection of some tumor markers. This project starts from studying the synergetic effect among the different metal atoms and the enhancing mechanism of 3D graphene toward the multi-catalytic centers embedded electrochemical interface. By coupling the tunable catalytic activity, physchemical stability, and sound biocompatibility, the specific biomolecules and the tumor markers can thus be detected electrochemically and alerted.

高灵敏度、高选择性的电化学传感领域的研究热点，构筑高催化活性、大比表面积、良好生物相容性、优异导电性的传感界面是推动新型电化学传感器性能提升的关键因素之一。本申请拟围绕三维石墨烯负载多元金属低维纳米晶的电催化特性耦合及协同效应，探索三维有序灵敏电化学传感界面的设计与优化，概要如下：1、水溶液体系清洁表面低维多元金属纳米晶的可控合成及协同催化机理研究；2、三维石墨烯-多元金属介孔有序电化学界面构筑及调控；3、多催化中心直接电化学界面的协同分子识别；4、基于三维石墨烯-多元金属复合纳米晶的电化学免疫传感器的设计及其对肿瘤标志物快速检测。本研究旨在探索多元金属的协同催化以及三维石墨烯负载对多催化中心界面增强机制，并结合多元金属纳米晶可调制优异催化活性、物化稳定性及良好生物相容性，用电化学分析手段实现对特定分子和某些重大疾病的快速发现和预警。

本项目以石墨烯和无机材料在催化和传感中的应用为基础，主要研究了高催化活性、大比表面积、良好生物相容性、优异导电性的电化学催化及传感界面的构筑，并尝试基于此界面探索新型电化学传感器并提升其性能。主要研究内容包括以下内容： 1、在水溶液体系中构筑低维多元金属纳米晶等催化及传感材料，并尝试研究其可控合成及协同催化机理；2、把上述合成的各类功能材料负载于三维石墨烯表面，尝试构筑介孔有序传感界面；3、基于多功能中心的直接传感界面的协同分子及力电识别；4、基于三维石墨烯-功能纳米材料的催化及传感器的设计。5.研究石墨烯负载对于传感特性的协同效应，并尝试拓展传感界面在其它领域的应用。