双金属铜基硫化物纳米光热材料的可控制备与肿瘤治疗的研究

Bimetal copper-based sulfide (CuxMySz) nanomaterials as photothermal agents probably can be widely used in cancer therapy due to their biodegradable and multifunctional properties. Currently, several bimetal copper-based sulfide nanocrystals, including Cu3BiS3, Cu5FeS4, and CuCo2S4 nanocrystals, have been successfully used in the diagnoses and photothermal therapy of cancers. However, these materials still remain some issues, such as undesirable photothermal/imaging performances and targeting. To solve the problems, this project will develop controlled chemical synthesis and surface modification to improve their photothermal/imaging performances and cancer targeting. Therefore, we will carry out this project to controllably synthesize bimetal copper-based sulfide nanocrystals with varied defect degree, morphology, structure, composition and size by chemical synthesis methods; these nanocrystals would possess both high photothermal conversion efficiency and excellent imaging performance. Then, we will modify their surfaces to obtain photothermal agents with outstanding biocompatibility and targeting. Finally, we will explore their toxicity, metabolism, targeting and theragnosis in vivo. Through the project, we will reveal the internal relationship among the surface composition/microstructure, photothermal/imaging performances, biocompatibility and targeting. This project can pave the way with beneficial theories and methods for the clinical research of bimetal copper-based sulfides in photothermal theragnosis therapy.

双金属铜基硫化物（CuxMySz）纳米光热材料因其具有可降解、多功能等优点可能被广泛应用于肿瘤治疗。目前已经有几种双金属铜基硫化物纳米晶成功用于癌症诊断与治疗，如Cu3BiS3、Cu5FeS4、CuCo2S4纳米晶。然而，这类材料存在光热/成像性能与靶向性不好等问题。为了解决该问题，本项目拟通过可控化学合成、表面修饰等手段，提高它们的光热/成像性能与肿瘤靶向性。为此，本项目拟通过化学法可控合成不同缺陷度、形貌、结构、组成、粒径的双金属铜基硫化物纳米晶，获得光热、成像性能俱佳的光热试剂；并研究双金属铜基硫化物纳米晶的表面修饰，改善其生物相容性和靶向性；最后，探索双金属铜基硫化物纳米晶在小鼠体内的毒性表现、分布转运及肿瘤靶向诊断与治疗的效果。通过本项目，揭示双金属铜基硫化物的表面组成、微结构与光热、成像、生物相容性与靶向性等性能之间的构效关系，为其用于肿瘤诊疗的临床研发奠定理论与方法基础。

双金属铜基硫化物（CuxMySz）纳米光热材料因其具有可降解、多功能等优点可能被广泛应用于肿瘤治疗。目前已经有几种双金属铜基硫化物纳米晶成功用于癌症诊断与治疗。然而，这类材料存在光热/成像性能与靶向性不好等问题。为了解决该问题，本项目拟通过可控化学合成、表面修饰等手段，提高它们的光热/成像性能与靶向性。为此，本项目拟通过化学法可控合成不同缺陷度、形貌、结构、组成、粒径的双金属铜基硫化物纳米晶，获得光热、成像性能俱佳的光热试剂；并研究双金属铜基硫化物纳米晶的表面修饰，改善其生物相容性和靶向性；最后，探索双金属铜基硫化物纳米晶在小鼠体内的毒性表现、分布转运及肿瘤靶向诊断与治疗的效果。通过本项目，揭示双金属铜基硫化物的表面组成、微结构与光热、成像、生物相容性与靶向性等性能之间的构效关系，为其用于肿瘤诊疗的临床研发奠定理论与方法基础。.我们通过化学法合成了多种具有高光热性能的纳米材料，包括CuCo2S4纳米晶体，AgFeS2纳米颗粒，Fe3S4纳米颗粒，CuS @ mSiO2核壳纳米颗粒，Ag / AgS2抑制结纳米颗粒，硫取代氧化 铁纳米颗粒，ReO3纳米立方块，MoO2纳米簇，Cu-TCPP金属有机框架纳米片，并将这些材料进行表面修饰，最后用于肿瘤或慢性血管疾病光热治疗。