异种VEGF受体的核酸疫苗抗肿瘤作用的研究

Abstract: Angiogenesis, the formation of new blood vessel, is important to the growth and invasion of cancer. Anti-angiogenic therapy has become a new therapy for cancer. By the way of DNA immunization and protein immunization, we use xenogeneic genes of vascular endothelial growth factors and their receptors to induce cross-link immune response between different sepices. And the auto-immune response may inhibit the growth of new blood vessel, then to induce the inhibition of the growth and invasion of cancer.

抑制肿瘤中的血管生成，从而抑制肿瘤的生长与转移，是目前研究治疗肿瘤的一个新方向。通过DNA免疫方法，将异种同源基因-与肿瘤中血管发生明显相关的血管内皮细胞生长因子受体导入体内，诱导机体产生种与种之间的交叉免疫反应，通过自身免疫反应阻止新生血管生长，从而抑制肿瘤生长。这将为异种蛋白、多肽、核酸疫苗免疫治疗肿瘤奠定基础。.