超声相控阵模拟中医针刺手法及其对骨癌疼痛的疗效研究

Acupuncture in the treatment of cancer pain has unique advantages, can reduce the body's opioid dependence. Insufficient quantitative study on the effect of Acupuncture limit the application of acupuncture in the treatment of cancer pain. This research project uses two-dimensional phased array to confirm the relationship of acupuncture manipulation and treatment of cancer pain.. In order to explore Corresponding relationship and curative effect difference between ultrasound and traditional acupuncture and mechanism investigation of the bone cancer pain research, two-dimensional phased array focusing to simulate acupuncture is used;According to the theoretical and Experimental Research on the characteristics and control strategy of the two-dimensional phased array focusing sound field, the ultrasonic phased array simulation system is built;Used Schlieren system to observe the dynamic changes of sound field, the relationship between the simulated acupuncture and the traditional acupuncture manipulation was analyzed from the movement pattern and the biological effect;Finally, duplicating rat bone cancer pain model, using von Frey pain measure instrument, thermal stimulate pain measure instrument, micro-CT etc, to research efficacy level of ultrasonic phased array Simulation acupuncture manipulation of bone cancer pain via different perspective e.g. pain behavior, imaging subject.Provides a new method for clinical research of acupuncture in the treatment of cancer pain ，the intersection of disciplines can promote the modernization of traditional Chinese acupuncture.

针灸治疗癌痛具有独特的优势，能减轻机体对阿片类药物的依赖性。传统针灸缺乏针刺效应的量化研究，限制了针灸治疗癌痛的应用。项目利用二维相控阵对此展开研究，从而量化针刺手法与治疗癌痛的关系。. 利用二维相控阵可任意位置聚焦的特点对传统针灸的提插捻转等手法进行模拟，探讨超声和传统针刺手法的对应关系和疗效区别，并对其骨癌止痛的机理进行研究。根据对二维相控阵聚焦声场特性及控制策略的理论和实验研究，搭建超声相控阵模拟针刺手法平台；利用Schlieren成像系统对聚焦声场的动态变化进行观察，从运动形态上和生物效应上分析模拟针刺和传统针刺手法对应关系；复制大鼠骨癌痛模型，采用von frey测痛仪、热刺激测痛仪、Micro-CT等方法从疼痛行为学、影像学等研究超声“针灸”对骨癌疼痛的疗效。为针刺治疗癌痛的临床应研究提供了新手段，超声学与中医学科交叉促进中医治疗现代化。

针灸治疗癌痛具有独特的优势，能减轻机体对阿片类药物的依赖性。传统针灸缺乏针刺效应的量化研究，限制了针灸治疗癌痛的应用。本项目研究了二维相控阵聚焦声场特性及控制策略，研制了256阵元的超声针灸相控阵探头和低强度聚焦超声控制系统，搭建了超声针灸实验平台，该平台可以实现声场在皮下的聚焦深度、角度、强度的可调（具体参数频率范围1MHz-3MHz可调、发射电压0V-100V连续可调，输出声强0-3W/cm2）。进一步探讨了超声二维相控阵模拟针刺手法的可行性和对应关系，并利用Schlieren成像系统实现了相控阵聚焦声场的可视化；复制大鼠骨癌痛模型，采用vonfrey测痛仪、热刺激测痛仪等方法从体重变化、疼痛行为学等研究超声“针灸”对骨癌疼痛的疗效。为针刺治疗癌痛的临床应研究提供了新手段，超声学与中医学科交叉促进中医治疗现代化。