GIRK2参与雌激素调节痛觉信息传递调制的机理研究
基本信息
结项摘要
G蛋白偶联的内向整流型钾通道亚型2（G-protein-activated inwardly rectifying potassium channel 2, GIRK2）是调节中枢神经元兴奋性的枢纽，是多种镇痛药物发挥作用的基础。与GIRK2相关的痛觉感知和镇痛疗效因性别而存在显著差异，同时有报道雌激素可作用于GIRK，由此推测它是介导雌激素参与痛觉信息调制的关键环节。本课题将从基因转录调控和蛋白修饰角度考察雌激素对GIRK2的作用，从G蛋白的信号转导角度更进一步揭示雌激素作用于GIRK2的机制；同时，观察雌激素对GIRK2的作用对阿片受体的影响。研究结果将为痛觉信息的调控机制带来新的认识，对阐明雌激素在神经系统中的作用具有重要价值，并为开发新的镇痛药物和方法开拓思路。
项目摘要
项目成果
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数据更新时间：2023-05-31
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