大气气溶胶细粒子（PM2.5）中痕量多环芳烃印迹萃取-近红外荧光快速检测研究

Trace polycyclic aromatic hydrocarbons (PAHs) existing in atmospheric aerosol fine particle (PM2.5) possess serious harm to human health, but it is difficult to quickly detect PAHs. The project aims to combine the advantage of high selective adsorption performance of molecularly imprinted materials and small background interference, stability, good performance of near-infrared fluorescent material, new type of near infrared fluorescent molecularly imprinted materials with high selective adsorption properties, high stability and quick adsorption performance will be prepared. Under the optimized extraction conditions, the trace PAHs in PM2.5 will be directly enriched with the molecularly imprinted materials. Combining with the high sensitivity of near-infrared fluorescence detection technology, online detection system based on imprinted extraction enrichment - near-infrared fluorescence detection will be established for rapid determination of trace PAHs in PM2.5. The extraction condition and test condition will be optimized based on chromatography-mass spectrometry detection results for rapid determination of trace PAHs in aerosol fine particle (PM2.5). Combined with a variety of adsorption models, adsorption mechanism of the near-infrared fluorescent molecularly imprinted materials toward PAHs in in aerosol fine particle (PM2.5) will be studied in detail. The study will simplify the sample pretreatment process of the PAHs from aerosol fine particle (PM2.5) and reduce the cost, which will open up a new way for the rapid detection of PAHs in atmospheric aerosol fine particle (PM2.5)

气气溶胶细粒子（PM2.5）中痕量多环芳烃对人类健康存在严重危害，但难以快速检测。该项目旨在结合印迹材料的高选择吸附性能和近红外荧光材料的背景干扰小、稳定性能好的优势，制备出高选择吸附性能、高稳定性和快速吸附性能的新型近红外荧光印迹材料。以印迹材料为吸附剂，优化萃取条件，直接将PM2.5中痕量多环芳烃选择性吸附富集；结合近红外荧光检测技术的高灵敏性，建立印迹在线萃取富集-近红外荧光快速检测系统。参照色谱-质谱联用检测结果，优化萃取条件和检测条件，实现对大气气溶胶细粒子（PM2.5）中痕量多环芳烃的快速检测。结合多种吸附模型，深入研究印迹萃取材料对气溶胶细粒子（PM2.5）中痕量PAHs的吸附机理。该研究将解决目前对大气气溶胶细粒子（PM2.5）中痕量多环芳烃检测样品前处理工艺繁琐和检测费用高的难题，为大气气溶胶细粒子（PM2.5）中痕量多环芳烃快速检测开辟一条新途径。

大气气溶胶细粒子中痕量污染物对人类健康存在严重危害，但难以快速检测。该研究以磁性碳点、植物碳点、碲化镉量子点、铜掺杂硫化镉量子点和可见光/近红外双发射荧光等为近红外荧光源，以新型功能材料为载体，结合印迹技术制备了一系列具有高选择识别性能和抗干扰能力的新型近红外荧光印迹材料。详细讨论了该近红外荧光印迹传感器对模板分子的荧光响应机理。结合荧光分析的高灵敏性和印迹材料的高选择性能，系列近红外荧光印迹材料成功应用于快速识别自来水样、食品、尿、血液和气溶胶中等实际样品中微量污染物、药物和蛋白的可视化快速灵敏分析，为现实环境中污染物、药物和蛋白质等大分子的高灵敏度、高选择性和可视化快速检测提供了一条新途径。该项目研究成果在国内外发表相关研究论文13篇，其中SCI收录10篇；科研成果获湖南省自然科学二等奖1项；培养研究生共12名，毕业5人，在读7人，获得湖南省优秀硕士论文1篇，校级优秀硕士毕业论文2篇，圆满完成项目的预期目标。