DNA去甲基化抑制涎腺腺样囊性癌生长、转移的实验研究
基本信息
结项摘要
启动子甲基化是抑癌基因失活的重要机制，而阻断DNA甲基化转移酶(DNMTs)可使抑癌基因去甲基化并重新表达，腺样囊性癌生长、转移与RASSF1A、E-cadherin基因甲基化密切相关。本研究拟构建DNMT1 siRNA重组腺病毒载体，转染腺样囊性癌细胞系Acc-2及高转移细胞系Acc-M细胞，并以DNMTs抑制剂Decitabine为对照，用RT-PCR、实时PCR、Western Blot、免
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数据更新时间：2023-05-31
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