超声造影对大鼠肝泡型包虫病浸润增殖区活性的评价

Hepatic alveolar echinococcosis(HAE) is a serious zoonosis.The lesion of hepatic alveolar echinococcosis show character of invasive growth in liver,The tissue of liver are damage chronically,The lesion of HAE can metastasizeto lung,brain and so on by blood and lymph at later-stage.At last,HAE can bring about liver cirrhosis,jaundice,portal hypertention,hepatic failure and cachexia,so HAE also named as "parasitic hepatic cancer" or "worm cancer".Prognosis of HAE is very poor,if effective therapy is short,the mortality of patient with HAE involved is about 90%～100%.Thus,the early diagnosis,antidiastole and radical treatment for HAE are still one of work with challenge.In auxiliary examination for HAE,imaging study play important role for diagnisis and follow-up of HAE.Formerly,we had done a lot of study for ultrasonogram of HAE,and how to imporve the accuracy rate of Colour Doppler Ultrasound for HAE,and applying of ultrasound contrast for HAE,and research about mini-blood in invasive breeding region of HAE so on.In following study,we hope to do research about metabolic activity in invasive breeding region of HAE by ultrasound contrast,and the change of invasive breeding region of HAE after treated by liposome albendazole.

肝泡状棘球蚴病（Hepatic alveolar echinococcosis，HAE）是一种严重的人畜共患疾病，HAE病灶在肝内呈浸润性生长，慢性损害肝组织，晚期可以随淋巴或血液转移，引起肺、脑等重要脏器继发性感染，最后可导致肝硬化、黄疸、门静脉高压和肝功能衰竭及恶病质，故有"寄生虫性肝癌"或"虫癌"之称，预后极差，如果不进行治疗，泡状棘球蚴患者的死亡率约为90%～100%。因此，HAE的早期诊断、鉴别诊断和根治性治疗目前依然是具有挑战性的工作之一。在其辅助检查中，影像学检查对于HAE的确诊和随访起着重要的作用。以往我们已经做了大量的研究关于HAE的超声声像图表现、如何提高彩超诊断HAE 的准确率、超声造影对肝泡状棘球蚴病灶的应用、HAE病灶浸润增殖区微血供的研究等，在进一步的研究中，我们期望运用超声造影研究HAE病灶浸润增殖区代谢活性的研究以及阿苯达唑脂质体治疗后浸润增殖区活性的改变。

肝泡状棘球蚴病（Hepatic alveolar echinococcosis，HAE）是一种严重的人畜共患疾病，HAE病灶在肝内呈浸润性生长，慢性损害肝组织，晚期可以随淋巴或血液转移，引起肺、脑等重要脏器继发性感染，最后可导致肝硬化、黄疸、门静脉高压和肝功能衰竭及恶病质，故有“寄生虫性肝癌”或“虫癌”之称，预后极差，如果不进行治疗，泡状棘球蚴患者的死亡率约为90%～100%。因此，HAE的早期诊断、鉴别诊断和根治性治疗目前依然是具有挑战性的工作之一。在其辅助检查中，影像学检查对于HAE的确诊和随访起着重要的作用。本研究运用超声造影技术，获得了HAE病灶周边活性的特征表现以及浸润增殖区活性的分级依据，以及运用阿苯达唑脂质体治疗后浸润增殖区活性的病理学改变及超声造影的评价。