热休克蛋白Hsp70在雌激素和雄激素对胞内淀粉样沉积Abeta 的抑制作用中的分子机制及通路
基本信息
结项摘要
细胞内淀粉样沉积Abeta?的积聚参与阿尔茨海默症（Alzheimer's disease, AD）的早期神经元死亡过程，胞内Abeta?水平的上调可能是AD的原发致病因之一（Zhang et al., 2002）。雌激素和雄激素可以有效地抑制胞内Abeta?的毒性，热休克蛋白Hsp70是参与这一保护性作用的重要因子（Zhang et al., 2004）。本研究利用人类原代培养神经元为实验模型，
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数据更新时间：2023-05-31
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