金属-黑碳颗粒物复合污染的界面自由基化学过程及其健康效应

It is urgently needed to investigate the formation processes of airborne particulate matter (PM) induced smog pollution events, which have been frequently occurred in China, and the relevant toxicological effects and possible toxicological pathways. Based upon that black carbon (BC) has been identified as the component most closely related to PM toxicity by recent studies and that metals-black carbon system, a form of complex pollution, inherently occurs due to adsorption of metals onto BC, this study is poised to further the understanding of the interfacial chemical processes, toxicity, and mechanisms of toxicity of metals-black carbon pollutants. Focusing on the interfacial free radical chemical processes on metals-black carbon particles, we propose here to investigate 1) the formation and dynamics of free radicals in the metals-black carbon heterogeneous interface; 2) the transformation of metal species induced by interfacial free radical reactions; and 3) the toxicity of metals-black carbon complex pollution being regulated by radical processes and metal species transformation, utilizing scavenging/quantification methods of free radicals and a combination of isotopic tracer and isotope dilution techniques. It is expected that this study will significantly advance our understanding of atmospheric chemical processes of metals-black carbon formation and evolution, and subsequent toxicity and mechanisms underlying toxicological effects of metals-black carbon complex pollution.

我国频发的大气雾霾事件使得大气细颗粒物毒性组分和致毒机制研究十分紧迫。针对最近研究表明黑碳是与健康效应最密切相关的大气颗粒物组分之一及我国大气中金属-黑碳颗粒物复合污染的特点，本项目致力于深入理解我国大气中金属-黑碳复合污染的界面化学过程、健康效应与致毒途径。以金属-黑碳界面自由基反应为核心过程，借助自由基捕获/测定技术以及组合同位素技术(多同位素示踪与同位素稀释)，本项目拟研究金属-黑碳颗粒物非均相体系界面的复合自由基生成途径、界面自由基化学反应介导的有毒金属形态转化过程、以及界面自由基反应和金属形态转化对金属-黑碳复合污染体系毒性增强/转化的新机制。本研究的目标是为准确理解金属-黑碳复合污染的大气环境化学过程，精确评估我国大气中细颗粒物的毒性组分、毒性效应及致毒机制提供科学依据。

我国频发的大气雾霾事件使得大气细颗粒物毒性组分和致毒机制研究十分紧迫。针对最近研究表明黑碳是与健康效应最密切相关的大气颗粒物组分之一及我国大气中金属-黑碳颗粒物复合污染的特点，本项目致力于深入理解我国大气中金属-黑碳复合污染的界面化学过程、健康效应与致毒途径。以金属-黑碳界面自由基反应为核心过程，借助自由基捕获/测定技术以及组合同位素技术(多同位素示踪与同位素稀释)，本项目研究了金属-黑碳颗粒物非均相体系界面的复合自由基生成途径以及界面自由基反应和金属形态转化对金属-黑碳复合污染体系毒性增强/转化的新机制。并研究了实际PM2.5颗粒对血管通透性的影响及分子作用机制。本研究为准确理解金属-黑碳复合污染的大气环境化学过程，精确评估我国大气中细颗粒物的毒性组分、毒性效应及致毒机制提供科学依据。