天然产物Matteflavoside G及其类似物的合成研究

Matteflavoside G is a flavonoid compound isolated from matteuccia struthiopteris in 2015. Matteucciastruthiopteris is a traditional Chinese traditional medicine, effective towards influenza . Matteflavoside G has excellent anti H1N1 activity which was better than ribavirin. It has potential to be a leading compound of anti H1N1 virus . This project intends to use small molecules catalyzed C-O formation as a key reaction to realize asymmetric total synthesis of Matteflavoside G, then constract a library containing Matteflavoside G type compounds with diversity oriented synthesis to screen H1N1 lead compounds.

Matteflavoside G 是2015年从荚果蕨中分离出来的一种黄酮类化合物。荚果蕨是我国传统传统药材的一种，有治疗流感等病症的功效。天然产物Matteflavoside G 的具有优良的抗H1N1的活性，数据优于已上市的广谱抗病毒药利巴韦林，具备成为抗H1N1病毒的先导化合物的潜力。本课题拟使用小分子催化的C－O键形成作为关键反应，完成Matteflavoside G 的不对称全合成，进而用多样性导向的合成方式构建具有Matteflavoside G 类似结构的化合物库，进而研究其活性规律，开发抗H1N1先导化合物。