基于脂联素的电针抗抑郁的机制研究

Existing research suggests that the concentration of adiponectin in hippocampus can affect the depression-like behavior in patients and rats. As one of effective treatments, acupuncture has been widely recognized to be an effective way to reduce depression. Acupuncture is able to improve coronary heart disease, type 2 diabetes and other diseases by regulating adiponectin concentration. However, studies on anti-depression by adjusting the concentration of adiponectin in hippocampus via acupuncture have not been reported. Therefore, this study aims to explore whether adiponectin in hippocampus is one of the important mechanisms for the anti-depression of electro-acupuncture. Based on previous studies, we use the chronic stress-induced depression model rats, select the effect platform of electro-acupuncture intervention depression, using animal behavior, molecular biology and tool interventions in specific brain area, to research the effect of adiponectin in hippocampus on anti-depression through electro-acupuncture. So as to provide a scientific experimental basis for the clinical treatment of depression and other neurodegenerative diseases.

现有研究认为，海马中脂联素浓度可影响抑郁症患者及大鼠的抑郁样行为，针刺作为有效改善抑郁症的治疗方法已被广泛认可，针刺可以调节脂联素浓度改善冠心病、二型糖尿病等疾病。然而，对于针刺通过调节海马中脂联素浓度抗抑郁的研究尚未报道。因此，本课题拟探索海马中脂联素是否作为电针抗抑郁的重要机制之一。在前期研究的基础上，以慢性应激诱导的抑郁模型大鼠为载体，选用电针干预抑郁症的效应平台，应用动物行为学、分子生物学、特定脑区工具药干预等方法，研究海马中脂联素在电针干预抑郁症中的效应变化，为抑郁症乃至其它神经变性疾病的针灸临床治疗，提供科学的实验依据。

现有研究认为，海马中脂联素浓度可影响抑郁症患者及大鼠的抑郁样行为，针刺作为有效改善抑郁症的治疗方法已被广泛认可，针刺可以调节脂联素浓度改善冠心病、Ⅱ型糖尿病等疾病。然而，对于针刺通过调节海马中脂联素浓度抗抑郁的研究尚未报道。因此，本课题探索了海马中脂联素是否作为电针抗抑郁的重要机制之一。在研究团队前期工作的基础上，建立了稳定的电针抗抑郁效应平台，完成电针治疗抑郁症中海马脂联素及其下游表达量的探索，并通过拮抗中枢脂联素探索电针抗抑郁的效应。同时，也建立了推拿抗抑郁效应平台，并对脂联素在推拿抗抑郁中的中枢和外周效应机制进行初步探索。为针刺治疗抑郁症的效应机制提供了一定的科学依据。目前本课题研究成果发表论文4篇（其中SCI源期刊发表2篇）。