NF-κB反义基因纳米粒靶向单核巨噬细胞防治脓毒症
基本信息
结项摘要
利用复凝聚法，制备含NF-κB反义基因片段的壳聚糖纳米粒(直径400-600nm)；通过体外细胞实验测定载基因纳米粒对单核/巨噬细胞相关基因、蛋白表达及其基因后效应的影响；在脓毒症模型静脉注射NF-κB反义基因纳米粒，利用单核/巨噬细胞吞噬功能实现特异靶向性，将载基因纳米粒导入单核/巨噬细胞，并由纳米粒缓慢释放NF-κB反义基因片段，以高度选择性的部分阻断单核/巨噬细胞内NF-κB作用，调控NF-
项目摘要
项目成果
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数据更新时间：2023-05-31
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