卵巢癌肿瘤干细胞特异性microRNA分子靶点调控的研究
基本信息
结项摘要
研究拟采用化疗和流式细胞分选结合的新方法进行卵巢癌肿瘤干细胞的富集和分选，并系统证明其分选的肿瘤干细胞性质和生物学行为特征，以求建立新的分离和富集卵巢癌肿瘤干细胞的方法。系统研究卵巢癌肿瘤干细胞形态和生物学特征的差异及其在增殖、黏附、侵袭、转移和自我更新、分化能力、成瘤能力等方面的特征并求证卵巢癌细胞在干细胞水平是否表达MISR II。通过比对和分析卵巢癌肿瘤干细胞和非干细胞在microRNA 表达谱的差异，寻找卵巢癌肿瘤干细胞特异性microRNA标志分子，并探讨卵巢癌肿瘤干细胞关键的microRNA分子表达的意义和调控机制。本研究将从卵巢癌肿瘤干细胞生物学特点和特异性microRNA分子表达的角度，进一步探讨卵巢癌复发、转移和化疗耐药的相关分子机制，寻找关键的分子靶点。研究结果将会为卵巢癌肿瘤干细胞研究提供新的方法和新靶标；为根本解决卵巢癌的复发、转移和耐药问题提供新的理论依据
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数据更新时间：2023-05-31
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