CtBP作为基因/组织特异的Wnt信号通路调节因子的机制研究
基本信息
结项摘要
Wnt信号通路在胚胎发育和癌症等疾病发生中起重要作用。Wnt信号通路在整个发育过程中被反复使用，呈现典型的基因/组织特异性。虽然目前对Wnt信号的转导途径已经有了深入的了解，然而我们对其基因/组织特异性的分子机制仍不十分清楚。CtBP是调节胚胎早期发育的重要共转录阻遏因子。最近有报道显示CtBP与TCF等共同形成转录阻遏复合物阻遏Wnt靶基因的表达。但是根据申请人以前的研究，CtBP阻遏Wnt靶基
项目摘要
项目成果
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数据更新时间：2023-05-31
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