5-HT诱导大鼠膈神经长时程易化的PKC信号通路机制研究
基本信息
结项摘要
婴儿猝死综合症、阻塞性睡眠呼吸暂停综合症等疾病常伴有中枢五羟色胺(5-HT)的释放，但不清楚其深层次的发生机制。我们预实验发现系统增加体内5-HT浓度，可产生浓度依赖的膈神经先抑制后兴奋的双重放电效应，兴奋效应持续并形成长时程易化(LTF),这些新发现可能提示睡眠状态下潜在的保护性觉醒机制的存在。同时形态学证实脑干呼吸节律产生中枢pre-B?tC内5-HT2A受体(5-HT2AR)和磷酸化蛋白激酶C (PKC)底物高表达。pre-B?tC是否通过5-HT激活的5-HT2AR、PKC途径参与LTF的调控？本项目拟采用形态学、电生理学、药理学等技术，以pre-B?tC为核心，以5-HT2AR、PKC为靶点，进行整体动物-离体脑片、中枢-外周、形态-功能结合的研究，明确pre-B?tC通过5-HT→5-HT2AR→PKC途径参与LTF调控的中枢机制，为上述疾病的预防和治疗提供实验依据和治疗对策。
项目摘要
项目成果
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数据更新时间：2023-05-31
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