非均匀液流中的光场调制机理及其在生化传感中的应用

The development of fast, accurate, low cost, small size biochemical micro- sensors is an urgent demand for real-time monitoring. However, the fluid flow in the on-chip sensor is usually non-uniform, which is facing new emerging challenges for the accuracy of optical detection. Optofluidics is a burgeoning interdisciplinary through the fusion of optics and microfluidics. This new research area promotes the advancements in optics, biology, and chemistry. In this research program, we propose to investigate and exploit light modulation in heterogeneous media by unique fluid dynamic properties such as diffusion, heat transfer, centrifugation etc., and the interaction between biochemical samples and light in flowing liquids. To solve the scientific problems of the interaction between light and flowing liquids in the optofluidc devices. On this basis, the theoretical results will apply to the research and development of novel optofluidic sensors. This proposal attempts to understand the novel photonic phenomena due to the interaction of fluids and light in micro- or nanoscale; and aims to exploit these novel phenomena to provide better solutions to new micro-/nano-optical devices, biological/chemical microsensors etc.

开发快速、准确、低成本、小尺寸的生物化学微传感器是目前实时监测应用亟需解决的问题。采用光学检测方法时，芯片中输送的待测液流通常呈现出非均匀特性，对检测结果的准确性提出了挑战。光流控是光学与微流控结合形成的交叉学科，这一崭新的研究领域促进了光学、生物、化学等领域的发展。本项目将研究光在流体的扩散、热传递、离心等动力学特性造成的非均匀介质下的调制机理，光与液流输送的生化样品的作用与反作用。解决光流控器件中光与液流的相互作用机理等重要科学问题，并在此基础上将理论成果应用于微传感器件的研制。本项目的研究对揭示光在微纳流体中的传播规律有重要的科学意义，将为新型的微纳光学器件、生化微传感器等一系列应用提供更好的解决思路。

开发快速、准确、低成本、小尺寸的生物化学微传感器是目前实时监测应用亟需解决 的问题。采用光学检测方法时，芯片中输送的待测液流通常呈现出非均匀特性，对检测结 果的准确性提出了挑战。光流控是光学与微流控结合形成的交叉学科，这一崭新的研究领 域促进了光学、生物、化学等领域的发展。本项目将研究光在流体的扩散、热传递、离心 等动力学特性造成的非均匀介质下的调制机理，光与液流输送的生化样品的作用与反作用 。解决光流控器件中光与液流的相互作用机理等重要科学问题，并在此基础上将理论成果 应用于微传感器件的研制。受项目资助，共发表标注资助SCI 论文24 篇，中文核心3篇，授权国家发明7 项，资助项目执行期间培养研究生 22 名，已毕业10 人，包括 8 名博士和 2 名硕士，另 12 人在读。本项目的研究对揭示光在微纳流体中的传播规律有重要的科学意义，将为新型的微纳光学器件、生化微传感器等一系列应用提供更好的解决思路。