c-met信号阻断对肿瘤转移能力的影响

To explore the role of c-met-SF/HGF parthway on metastasis potential of cancer.Biology and molecular methods were used to check SF/HGF and c-met gene express in the hepatocellular carcinoma(HCC) cell lines with higher and lower metastasis potential.The results provide that the auto-stimulation of c-met-SF/HGF signal system is one of cancer metastasis characters which is first investigated. The auto-stimulation of signal parthway play the important role in development and metastasis potential of HCC and inhibition and block of c-met signal transduction system may reduce the cancer growth and metastasis.

c-met的激动与过表达与肿瘤的转移，生长密切相关，本研究试图通过不同水平的抑制met的表达来观察肿瘤细胞的肿瘤形成，转移能力的改变，以及与其他生长因子的关联，为进一步研究细胞信息传导及抗肿瘤转移的新研究提供基础。.