致癌物与DNA形成加合物的基因作用靶点筛选研究
基本信息
结项摘要
遗.传.毒.性.致.癌.物.通.过.与.DNA.形.成.加.合.物.而.引.起基.因.损.伤.，.致.?物.与.基.因.的.作.用.有.一.定.倾.向.性，.即.存.在.基.因.作.用.靶.点.。.本.项.目.将.借.鉴.SELEX.原理.，.建.立.一.种.筛.选.致.癌.物.基.因.作.用.靶.点.的.新.方法.：.将.致.癌.物.与.随.机.寡.核.苷.酸.库.相.互.作.用.，.然后.分.?出.形.成.加.合.物.的.核.酸.序.列.，.再.经.PCR.放大.，.反.复.循.环.几.次.，.克.隆.、.测.序.，.即.可.筛.选.出靶.点.序.列.，.然.后.与.已.知.人.类.基.因.?序.列.比.较.。.
项目摘要
项目成果
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数据更新时间：2023-05-31
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