为证实CVB的BC环为中和抗原表位,以CVB3的BC环的核酸序列为突变引物,用基因定点突变际踅淝逗现罜VB1,以蛋白印迹及中和试验阐明其免疫原性。构建CVB1/3VP1嵌合表位的真核表达系统,以蛋白印迹、ELISA及中和试验阐明其免疫性状,以病毒攻击保护实验探讨其孕募⊙椎淖饔谩N狢VB嵌合表位核酸疫苗提供理论依据。
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数据更新时间:2023-05-31
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