碘摄入量变化对自身免疫甲状腺病影响的前瞻性研究

The present study focused on the fact of the increasing incidence of thyroid disorders after USI in China. The group did epidemiological survey in 3 rural communities with different iodine intake. Basic study on mechanism of iodine induced AITD was done also. We found from the epidemiological study that the prevalence of hypothyroidism and papillary thyroid cancer increased with the increment of iodine intake. Basic study indicated that iodine as an important environmental factor, might play a stimulative role in the development of AITD. We also found evidence for linkage on chromosome 5q31 in Chinese Han pedigree by genome-wide scan of Graves' disease. 18 articles has been published during the 3 years and the results are paid great attention to.

本项目拟通过前瞻性干预研究探讨碘摄入量变化对于具有遗传倾向的易感人群发生临床自身免疫甲状腺病（AITD）的影响，并从易感个体的针对甲状腺的特异性自身免疫T、B细胞的机能和自身免疫攻击的靶腺－－甲状腺细胞的HLA－Ⅱ类抗原和粘附分子异常表达方嫜芯科浞⑸疲诜乐蔚丶撞」ぷ髦卸訟ITD易感人群科学掌握补碘剂量提供理论基础