神经节丛消融对心房颤动犬心房自主神经重构的影响

Atrial fibrillation is one kind of clinical common tachyarrhythmia. It can cause stroke, heart failure and increase all-cause mortality. Currently, radiofrequency ablation therapy is an important treatment for patients of atrial fibrillation to restore and maintain sinus rhythm, but the success rate is still low. The mechanism of atrial fibrillation is complex. The remodeling and imbalance of atrial autonomic nerve is one of the important mechanisms of atrial fibrillation. As shown in previous study, the ablation the ganglionic plexi can change the distribution of Atrial autonomic nerve. In recent years, much work has been done about ganglionic plexi ablation, but the effect is still controversial. How ganglionic plexi ablation affect the autonomic innervation remodeling is an urgent problem to solve. This project is designed to answer the question. We will study the effect of different strategies of ganglionic plexi ablation on the remodeling of atrial sympathetic and vagal nerve. When this project completed, we can see whether ganglion plexus ablation could rebalance the atrial autonomic nervous system.

心房颤动是一种临床常见的快速心律失常，可引起卒中，心力衰竭并增加全因死亡率。目前，房颤射频消融治疗是使患者恢复并维持窦律的重要治疗手段，但其成功率仍较低。房颤的机制复杂，其中自主神经的重构和失平衡是促进房颤发生与维持的重要机制之一。已有研究显示，消融神经节丛能改变心房自主神经的分布。近年来，国际上针对神经节丛消融进行了较多探索，但疗效仍有争议。神经节丛的消融如何影响房颤心房自主神经的重构是急需明确的问题。本课题将利用心房颤动犬动物模型进行研究，比较选择性消融左房神经节丛、右房神经节丛以及全面消融心房神经节丛对心房交感、迷走神经重构的影响，以明确神经节丛消融是否能够实现心房自主神经的再平衡。