Toll样受体信号途径中TRAF6的调控机制
基本信息
结项摘要
Toll样受体是人体固有免疫系统中识别病原体的主要模式识别受体，其细胞内信号传递直接导致了转录因子NF-κB,AP-1,IRF3/7的激活，引发细胞抗病毒、细菌的固有免疫反应，并进一步激活获得性免疫反应。TRAF6是Toll样受体信号途径中共同的关键性信号分子，它作为接头蛋白将受体信号复合物的信号传递给下游转录因子的激活因子；同时还作为E3泛素连接酶对自身进行修饰性泛素化调控。本项目的研究目的是通过克隆与TRAF6相互作用的蛋白，进一步研究TRAF6在各种Toll样受体信号途径中的功能和调控机制。
项目摘要
项目成果
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数据更新时间：2023-05-31
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