基于氧化铈纳米粒子的多功能载药体系的构建

Cerium oxide nanoparticles (CeONPs) have received much attention because of their excellent catalytic activities, which are derived from quick and expedient mutation of the oxidation state between Ce4+ and Ce3+. Being a mature engineered nanoparticle with various industrial applications, CeONP was recently found to have multi-enzyme. These make it have many potential applications in biological fields. Recent years, the pharmacological potentials of CeONP for many diseases have been discovered, especially for oxidative stress-related diseases, such as neurodegenerative disorders. It is also reported that CeONP has both direct cytotoxicity and indirect anti-invasive properties on tumor cells. Taking advantage of the biological activities of CeONP, in this project, we proposed to construct drug delivery systems based on it. In these systems, CeONP not only act as drug carries, but also had assisted therapy effects. Targeting molecules were also introduced in, and this project focuses on the construction of a series of multifunctional nanocarries based on CeONP with “target”, “vector” and “treatment” together. Up to now, CeONP is just used as drugs in most studies for applications in disease treatmet, the concept proposed in this project may open up new avenues for future CeONP applications.

氧化铈纳米粒子由于具有优越的催化性质而备受关注。它的催化性能来源于其可快速的在Ce4+/Ce3+ 之间的转变。作为一种有着众多工业应用的成熟的工程材料，近年来发现氧化铈还具有多重生物酶的活性。这使其在生物方面有着众多极具前景的潜在应用价值。近期研究表明氧化铈具有众多潜在的药理活性，特别是在治疗氧化损伤类疾病，如神经退行性疾病等有着非常可观的潜在应用价值。还有一些报道表明氧化铈对癌症细胞有着直接的杀伤作用及抗迁移作用。鉴于其众多的生物活性，在此项目中我们提出构建基于氧化铈的药物运载体系。在这些体系中，氧化铈不仅仅作为药物载体，同时还有辅助治疗作用。靶向分子同样被引入，该项目旨在构建一系列集“靶向”、“载体”和“治疗”于一身的一系列基于氧化铈的多功能载体。目前对氧化铈在疾病方面的研究仅仅作为单纯的药物使用，本项目提出的理念将为氧化铈的未来应用开辟新的思路。

目前纳米材料在药物输送和疾病治疗技术方面已受到广泛的瞩目和研究。由于纳米尺寸，它们较易被富集到患病细胞，可以用于直接治疗疾病，改善药物递送功效，减少副作用，并且总体上改善人类健康。最近，一些纳米材料被发现具有类似天然酶的催化活性，使其不仅用作药物载体，而且还具有协同治疗作用以提高药物的效率，甚至可以是药物本身。其中，氧化铈纳米粒子（CeONPs）由于其良好的催化活性而倍受关注，这些催化活性源于Ce4 +和Ce3 +之间氧化态的迅速而迅速的突变。据报道，它们具有多重酶模拟活性，包括超氧化物氧化酶，过氧化氢酶，氧化酶，以及磷酸酶等，已经在生物医学领域成为一种非常有应用前景的材料。但是，由于氧化铈纳米粒子以及其他纳米酶的的多重酶模拟活性，需要开发一种通用的调控方法，使这些纳米酶可以根据疾病所需发挥适宜的酶活性。在这个项目中，我们构建了基于纳米材料/纳米酶的疾病治疗系统，并通过近红外（NIR）和紫外（UV）光敏纳米材料的组合，开发了一种通用的纳米酶活性光调控方法。我们希望这个项目提出的方法可能为未来的纳米材料应用开辟新的途径。