IL2R介导的恶性血液淋巴细胞凋亡诱导分子
基本信息
结项摘要
选择性清除细胞被认为是肿瘤，尤其是血液系统肿瘤生物治疗的可能途径之一。但现有细胞选择性清除分子主要由非人源的杀伤毒素构成，且分子量较大，具有强烈的免疫原性，容易诱导抗体产生。.引入细胞凋亡诱导机制，促进肿瘤细胞凋亡可能是肿瘤生物治疗的新方法。项目提出利用人源促细胞凋亡分子Bid和Cyt C等分子与IL2连接，组建系列新分子并分析其对IL2R阳性细胞的选择性清除作用及机制。利用人源功能片段组建的融合
项目摘要
项目成果
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暂无此项成果
数据更新时间：2023-05-31
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