1A6/DRIM与NIR的相互作用及对NIR的功能调节
基本信息
结项摘要
我们发现1A6/DRIM定位于细胞核仁，表达被阻断后，乳腺癌细胞的转移能力下降；18S rRNA加工被抑制；同时1A6/DRIM在细胞内与U3 snoRNA结合。U3 snoRNA在18S rRNA加工过程中引导与其结合的蛋白质复合体到18S rRNA的前体上，对其前体进行剪切加工。本课题将对1A6/DRIM与U3 snoRNA结合的分子机制进行研究并分离1A6/DRIM相关的蛋白质复合物。我们还发现1A6/DRIM与NIR结合，NIR与p53直接结合并抑制p53的转录功能，在细胞周期和凋亡调控中发挥重要功能。我们的实验证明1A6/DRIM与NIR的结合是不依赖于p53的。我们将对1A6/DRIM与NIR结合的分子机制及1A6/DRIM与NIR结合后对p53转录功能的调控进行研究。旨在阐明1A6/DRIM在细胞生命活动的重要功能及其分子机制，并明确1A6/DRIM在肿瘤转移的中的作用。
项目摘要
项目成果
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数据更新时间：2023-05-31
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