基于MEMS的血液中微量元素的快速检测方法研究

For the strong relationship between the health of human body and the content of trace elements, there are about 30% of the diseases causing by imbalance or lack of trace elements. Portable fast online detection of trace elements in human blood will provide the reliable data support for diagnosis of some diseases, and also give the essential heathy infoemation. To now, there are lots of detection method for trace elements in human body, which cannot meet the practical medical demand, especially to monitor nano-liter blood samples. This project intends to carry out the research on the fast detection method of trace elements based on Micro-Electro-Mechanical System (MEMS), mainly including the efficiently pretreatmeat of nano-liter blood samples by microwave digestion, the sensitivity and limit of microelectrode detection, multiple trace elements monitoring . The project combines with microwave digestion pretreatment and microelectrode measuring method, which will bring a noval detection methods of trace elements in nano-liter blood samples, and establish the theoretical and experimental basis for the development of fast online detection of trace elements in human blood.

人体的健康与体内微量元素的含量有很大关系，人体约30%的疾病与微量元素缺乏或不平衡相关。血液中微量元素的快速、在线和便携检测可以为某些疾病的诊断提供快速可靠的数据支持，同时也方便人们随时随地了解自身的健康状况。目前，血液中微量元素检测方法众多，但都难以满足快速、在线检测的需求，特别是针对纳升级的血液样本。本项目拟开展基于微机电系统（MEMS）技术的微量元素的方法研究，具体包括快速高效的纳升血液样本的微波消解处理，微电极检测的灵敏度和检测上限的提高，血液中多种微量元素的同时检测等。本项目创新性的结合微波消解前处理和微电极电化学检测方法，从而可以实现对纳升级血液样本的处理和微量元素的检测，为研制血液中微量元素的快速在线检测仪器提供理论依据和实验基础。

本项目针对血液及环境中微量重金属精确、快速和在线检测需要开展研究，研究基于生物传感、光激化学发光及微机电系统技术（MEMS）微量元素的微电极电化学检测方法研究，具体研究内容包括快速高效的纳升级血液样本的微波消解与微电极检测方法，高效率重金属检测生物传感器设计，基于光激化学发光的多种重金属同时检测方法研究等。.本项目解决的关键科学问题以及创新性工作包括，提高样品微波消解效率，提高重金属检测精度、灵敏度和检测范围，实现多种微量元素同时检测。研究方案基于生物传感，光激化学发光及MEMS 技术，创新性的结合微波消解前处理和微电极电化学检测方法，从而可以实现对纳升级血液样本的处理和微量元素的检测，为研制血液中微量元素的快速在线检测仪器提供理论依据和实验基础。