实验诱发的益处发现对乳腺癌患者预后影响的心理和生理机制研究

Breast cancer is one of the most common malignancies in women, which is featured with high morbidity, high mortality and patients with young age. Several studies found that women with breast cancer obtained various positive changes in their cognition and behaviors during the diagnosis and treatment of breast cancer, which is called "Benefit finding". Benefit finding provides a brand-new perspective for researching the psychological and physiological rehabilitation in women with breast cancer, but it is unclear that how benefit finding affects the prognosis of breast caner from the aspects of psychology and physiology. In this project, we use a experimental and long-term longitudinal study to explore: 1) the effects of psychological, sociodemographic and pathological factors on the effectiveness of experimental intervention during different periods of breast cancer treatment; 2) the effects of benefit finding on psychological and physiological factors during different periods of treatment in women with breast cancer; (3) the psychological and physiological mechanisms of the effects of benefit finding induced by experiments on prognosis in breast cancer patients, by a combined research method of clinical interview, psychological assessment and detection of biological indicators. This project aims to establish a effective and easy-to-operate paradigm of positive psychological intervention for women with breast cancer, as well as to elucidate the psychological and physiological mechanism of the effects of benefit finding induced by experiments on prognosis in women with breast cancer, which will provide theoretical and practical evidence for carrying out positive psychological interventions in order to improve their quality of life and lengthen their survival time scientifically and effectively.

乳腺癌是女性最常见的恶性肿瘤之一，且呈现出高发病率、高死亡率和患者低龄化的特点。研究发现乳腺癌患者能够从乳腺癌的诊断和治疗中获得认知和行为等多方面的积极改变——“益处发现”。益处发现为乳腺癌身心康复领域的研究提供了全新的视角，但益处发现对乳腺癌患者预后影响的生理和心理机制尚不明确。本项目拟通过实验干预手段，将临床访谈、量表评估和生化指标检测三种方法相结合，采用长时程追踪实验设计，探索：1）心理-社会-病理学因素在不同治疗期对实验干预有效性的影响；2）不同治疗期实验诱发的益处发现对乳腺癌患者多项心理和生理指标的影响；3）实验诱发的益处发现对乳腺癌患者预后影响的心理和生理机制。本项目拟建立针对乳腺癌患者的科学有效且易操作的积极心理干预模式，同时阐明实验诱发的益处发现对乳腺癌患者预后影响的具体作用机制，为旨在提高乳腺癌患者生命质量和生存期的积极心理干预的顺利开展提供科学有力的理论和实践证据。