VEGF诱导的Kv1.2酪氨酸磷酸化在其缺血神经保护效应中的作用及其机制研究
基本信息
结项摘要
研究显示血管内皮生长因子（VEGF）对细胞膜外向延迟整流钾电流及Kv1.2钾通道的酪氨酸磷酸化有快速的调节作用，可能与其缺血神经细胞保护效应相关。本项目的研究目的是明确VEGF对Kv1.2磷酸化快速调节效应的作用及其机制，通过免疫组化、基因knock down、免疫沉淀、定点突变、膜片钳等技术，确定VEGF受体是否参与这一快速调节效应，明确受VEGF调控的Kv1.2的磷酸化位点，并通过突变这些磷酸
项目摘要
项目成果
{{i.achievement_title}}
{{i.achievement_title}}
暂无此项成果
数据更新时间：2023-05-31
其他相关文献
Efficient photocatalytic degradation of organic dyes and reaction mechanism with Ag2CO3/Bi2O2CO3 photocatalyst under visible light irradiation
Efficient photocatalytic degradation of organic dyes and reaction mechanism with Ag2CO3/Bi2O2CO3 photocatalyst under visible light irradiation
Empagliflozin, a sodium glucose cotransporter-2 inhibitor, ameliorates peritoneal fibrosis via suppressing TGF-β/Smad signaling
Empagliflozin, a sodium glucose cotransporter-2 inhibitor, ameliorates peritoneal fibrosis via suppressing TGF-β/Smad signaling
An alternative conformation of human TrpRS suggests a role of zinc in activating non-enzymatic function
An alternative conformation of human TrpRS suggests a role of zinc in activating non-enzymatic function
Baicalin provides neuroprotection in traumatic brain injury mice model through Akt/Nrf2 pathway
Baicalin provides neuroprotection in traumatic brain injury mice model through Akt/Nrf2 pathway
IRE1-RACK1 axis orchestrates ER stress preconditioning-elicited cytoprotection from ischemia/reperfusion injury in liver
IRE1-RACK1 axis orchestrates ER stress preconditioning-elicited cytoprotection from ischemia/reperfusion injury in liver
邱梅红的其他基金
相似国自然基金
Hsp20及其磷酸化在脑缺血再灌注损伤中的神经保护作用
心肌缺血后适应保护效应中神经源性机制研究
NMDA受体GluN2B亚基酪氨酸磷酸化调控新机制及其在脑缺血损伤中的作用
VEGF促进缺血损伤诱导成年脑内非神经发生区的神经元再生作用的分子和细胞机制