固相合成寡糖用新型载体材料的研究

Monodisperse polyvinylbenzene-divinylbenzene (PSTDVB) particles (5-50 mm) were prepared using one-step seed polymerization. Through adding linear polyvinylbenzene in the monomers, 50% cross-linked monodisperse polymer particles with supermacroporous were obtained. After chloromethylation, the particles were treated with polyethynol having 3-5 units, and the disiered material was got. This particles will be used as supporting material for synthesis of oligosaccharides in solid phase. Meanwhile, a lot of strategies for synthesis of oligosaccharides having various structures were developed in solution phase.

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