以趋化因子受体CCR7和CXCR4为靶点的双靶点拮抗剂抑制乳腺癌转移的实验研究
基本信息
结项摘要
据最新的关于趋化因受体/配体CCR7/CCL21和CXCR4/SDF-1分别相互作用驱动乳腺癌细胞从原发灶定向远距离转移至淋巴结和肺、肝脏、肾及骨髓等组织的转移分子机制，借鉴趋化因子遗传改造筛选受体特异性拮抗剂的最新研究成果，本项目拟对CCR7的天然配体CCL21进行多位点定向遗传改造、筛选出CCR7的特异性拮抗剂，再利用无侧链、易旋转的四联体甘氨酸短肽（-Gly-Gly-Gly-Gly-）与具有
项目摘要
项目成果
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暂无此项成果
数据更新时间：2023-05-31
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