高原人群呼吸障碍的发生及其遗传基础研究

Exposure to hypobaric hypoxia at altitude induces breathing disorders. Breathing disorders at high altitude are related toabnormal ventilatory control, mainly manifesting as depressed hypoxic responsiveness. There are considerable variations in the breathing disorders and ventilatory control in the populations at altitude, and between Tibetan residents and Han residents. The variations are likely to be influenced by genetic factors. We plan to measure the hypoxic ventilatory response during daytime and sleep, and detect HLA class II gene status in newcomers at altitude, and in Tibetan and Han high-altitude residents, in order to understand the impact of acute and chronic hypoxic exposure on breathing disorders in populations at altitude, the altitude acclimatization, the individual variations, and the national differences of the ventilatory control. The role of HLA class II gene on the pathogenesis of breathing disorders andventilatory control will be explored further.

暴露于高原低氧低气压环境会诱发呼吸障碍，而高原呼吸障碍的发生与呼吸调节功能异常相关，主要表现为呼吸中枢低氧反应性下降。高原人群出现的呼吸障碍和呼吸调节功能异常存在很大的个体差异，且在藏族和汉族人群中也存在差异，而这种差异可能具有遗传基础。我们拟对初入高原人群和久居高原的藏族及汉族人群进行清醒及睡眠时呼吸中枢低氧反应性测定及HLA II类基因测定，了解急慢性低氧暴露对高原人群呼吸障碍的影响、呼吸障碍的高原适应性变化及其个体、民族差异，并探讨HLA II类基因在呼吸障碍的发生和呼吸调节中的作用。

高原呼吸障碍的发生与呼吸调节功能异常相关，主要表现为呼吸中枢低氧反应性下降。高原人群出现的呼吸障碍和呼吸调节功能异常存在很大的个体差异，且在藏族和汉族人群中也存在差异，而这种差异具有一定的遗传基础。我们对初入高原人群和久居高原的藏族及汉族人群进行清醒及睡眠时呼吸中枢低氧反应性测定，对于急慢性低氧暴露对高原人群呼吸障碍的影响、呼吸障碍的高原适应性变化及其个体、民族差异进行了初步探讨，由于三年的疫情影响，初入高原的汉族人群较疫情前有了明显的减少，导致后期对于不同人群的HLA II类基因测定工作受到影响，目前社会各项工作恢复正常，对HLA II类基因在呼吸障碍的发生和呼吸调节中的作用的研究工作仍在继续。