酒石酸衍生物手性MOFs的构筑及在气相色谱中分离对映体小分子

This project aims at designing novel chiral MOFs with modified L-tartaric acid ligands that are synthesized by condensation reaction of carboxyl and amino groups, with linear aromatic bicarboxylic acids or bipyridine derivatives as auxiliary ligands to adjust size and shape of cavities inside. By modulating MOFs morphology and choosing uniform particle size distribution, high performance chiral MOFs as filling materials, chiral capillary chromatographic columns are prepared and tested to separate medically and industrially important enantiomer small molecules. The chiral recognization and separation mechanism between MOFs and guest organic molecules will be investigated, which may provide theoretical basis for future application of chromatographic columns with chiral MOFs stationary phase in analytical chemistry.

本项目拟选取手性酒石酸分子为原料，利用羧基与氨基的缩合反应，设计合成手性酒石酸衍生物配体，辅以线性芳香羧酸或吡啶配体与过渡金属构筑手性多孔MOFs材料。通过形貌调控，筛选粒径分布均匀、性能优良的手性纳米MOFs材料，制备手性毛细管气相色谱柱，对重要的医药、工业对映体小分子进行分离研究，揭示MOFs结构与手性分离的机理，本课题为设计新型手性色谱柱材料及手性MOFs材料在分析领域的应用提供指导。

手性分离已经成为立体化学和生物活性化合物、药物工业的一项重要的任务，因为对映体通常表现出不同的生物活性和药理反应。本项目分别用手性配体和对非手性配体体系进行手性诱导的方法构筑了几个手性多孔MOFs材料，在D3对称性[(NaO3)Co3]基的手性磁体中，实现了从自发分辨到绝对手性诱导。四重螺旋链基SBUs的手性MOFs进行了手性识别α-羟基/氨基酸研究。平面Mn4O簇基的手性MOF和四重穿插的[Ni(pybz)2]分别制备液相和气相色谱柱，分离手性药物布洛芬等。