手性纳米孔MOFs材料的设计合成及其在气相色谱中手性拆分的应用

Resolution of chiral compounds especially splitting of some drug molecules has become an important factor to affect the development of national economy and the people's health. Separation of chiral compounds by gas chromatography has the advantages. However, there are limited chiral stationary phase materials which restricted the development of resolution of chiral compounds in gas chromatography. Therefore, people urgently need to find a suitable new materials of gas chromatographic chiral stationary phase. Chiral nanoporous MOFs has adjustable structure, high specific surface area, good absorbability and stability which make it suitable as chromatographic stationary phase materials. This project will focus on resolving some drug molecules and Synthesis of intermediates of chiral compounds, and find a new direction for the development of gas chromatography chiral stationary phase material. Firstly, organic synthesis technology and crystal self-assembled principle will be used to design and synthetize. Then, dynamic coated method will be adopted to assemble chiral mesoporous MOFs that have good thermal stability in the inner wall of capillary column, preparation of capillary chiral stationary phase, combined with the chiral separation technology, explore novel chiral nanoporous MOFs materials for the splitting of gas chromatography with chiral stationary phase of chiral molecules, developing new field for gas chromatography chiral stationary phase, and providing new ideas and methods for splitting of chiral compounds.

手性化合物的拆分特别是一些药物分子的拆分已成为影响国民经济发展和人们健康的重要因素。气相色谱分离手性化合物具有很好的优越性，然而手性固定相材料受限，这制约了气相色谱拆分手性化合物的发展。因此，人们迫切需要寻找合适的气相色谱手性固定相新材料。手性孔MOFs因具有结构可调，比表面积高，吸附性和稳定性好等特点，使其适合作为色谱固定相材料。本项目将重点拆分一些药物分子以及合成中间体等手性大分子化合物，为气相色谱手性固定相材料的开发寻找新的方向。首先，运用有机合成技术和晶体自组装原理等手段，设计合成手性孔MOFs材料；在此基础上，采用动态涂渍法将热稳定性好的手性孔MOFs材料组装在毛细管柱内壁，制备毛细管手性固定相；结合手性拆分技术，探索新型手性孔MOFs材料为气相色谱手性固定相对手性分子进行拆分的机理和规律，为气相色谱手性固定相的发展开拓新的领域，为手性化合物的拆分提供新的思路和方法。

金属-有机骨架 (MOFs) 化合物具有结构可调，比表面积高，吸附性和稳定性好等特点。因此，金属-有机骨架化合物在新型材料方面得到了快速的发展。本研究运用有机合成技术，合成具有不同基团不同链长的有机配体，在晶体工程自组装原理的指导下，我们选取了含有多个羧酸的V型配体和线型的具有活性位点的含氮配体为主配体，制备孔径可调且具有活性位点的纳米孔MOFs材料。课题组对合成的孔MOFs材料进行结构表针和性能测试，筛选稳定性好的孔MOFs材料，研究其荧光传感性质、电化学传感性质、分离性质及拓扑学分析，探索性能和拓扑结构关联的参数，为定向合成多孔MOFs材料提供新思路，丰富了多孔MOFs材料的种类，为多孔MOFs的构效关系提供一定的理论依据。