JAK2调控IL-5/IL-5R信号转导的分子机制
基本信息
结项摘要
IL-5对B细胞、Eos等细胞的增生、分化和功能发挥有重要作用，与哮喘、寄生虫病、肿瘤、移植排斥等多种疾病相关。JAK2是IL-5信号转导通路中的重要信号分子，不仅参与IL-5信号传递，还对IL-5信号转导有调节作用。JAK2可与dynamin-2结合，介导IL-5/IL-5R的内吞降解，但具体机制尚不清楚。同时JAK2各个结构域在信号调节中所起作用仍未阐明。本课题拟通过分子模拟研究JAK2和dynamin-2的结构和功能，根据模拟结果构建JAK2突变体，与IL-5Rα、β链共转染DN－JAK2细胞，研究JAK2突变体能否通过dynamin-2介导IL-5/IL-5R内吞调节IL－5/IL-5R信号转导，并检测下游的信号分子和骨架运动相关分子，研究JAK2对IL-5信号传导的具体调节机制，为更好地理解JAK2在IL-5信号转导中的作用提供新思路。
项目摘要
项目成果
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数据更新时间：2023-05-31
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