Skp2作为AKT效应分子调控肿瘤细胞异常增殖的机制研究
基本信息
结项摘要
Skp2是泛素－蛋白酶体通路中与细胞周期相关的E3连接酶－SCF复合物中的底物识别亚基，本项目旨在揭示Skp2作为AKT的效应分子调控肿瘤细胞异常增殖的分子机制。研究内容：1）构建Skp2突变体，分析AKT和Skp2之间的相互作用及其相互作用区域，同时分析AKT对Skp2的体内外磷酸化修饰作用及其磷酸化位点；2）以AKT活化的HeLa细胞为模型，分析Skp2突变体S72A（失活）和S72D（活化）
项目摘要
项目成果
{{i.achievement_title}}
{{i.achievement_title}}
暂无此项成果
数据更新时间：2023-05-31
其他相关文献
Low level of 5-Hydroxymethylcytosine predicts poor prognosis in non-small cell lung cancer
Low level of 5-Hydroxymethylcytosine predicts poor prognosis in non-small cell lung cancer
Identification and Antioxidant Activity of a Novel Peptide from Baijiu
Identification and Antioxidant Activity of a Novel Peptide from Baijiu
Glycyrrhetinic Acid Protects Renal Tubular Cells against Oxidative Injury via Reciprocal Regulation of JNK-Connexin 43-Thioredoxin 1 Signaling
Glycyrrhetinic Acid Protects Renal Tubular Cells against Oxidative Injury via Reciprocal Regulation of JNK-Connexin 43-Thioredoxin 1 Signaling
FOXG1 Directly Suppresses Wnt5a During the Development of the Hippocampus
FOXG1 Directly Suppresses Wnt5a During the Development of the Hippocampus
Rapid development of stable transgene CHO cell lines by CRISPR/Cas9-mediated site-specific integration into C12orf35
Rapid development of stable transgene CHO cell lines by CRISPR/Cas9-mediated site-specific integration into C12orf35
钱俊杰的其他基金
相似国自然基金
CSMD3通过调控SKP2表达促进食管鳞癌细胞异常增殖的分子机制研究
基于肿瘤细胞的异常脂代谢探讨千层纸素调控肿瘤细胞增殖及分化的分子机制
胃癌循环肿瘤细胞EMT过程中PI3K-AKT-miRNA-200s信号通路异常表达的分子调控机制研究
TGFBI基因缺失调控细胞增殖及肿瘤进展的分子机制