腹外侧眶皮层内多巴胺及其受体亚型抗神经病理痛的作用机制
基本信息
结项摘要
腹外侧眶皮层（VLO）微注多巴胺（DA）D1和D2受体激动对L5/L6脊神经结扎诱发大鼠神经病理痛的抑制效应，和其拮抗剂对各自效应的影响，及GABAA激动剂和拮抗剂对D2激动剂抑制效应的影响；用免疫组化、束路追踪与免疫电镜观察VLO内D1、D2 受体在神经元或末梢的分布特征，VLO投射神经元与GABA能中间神经元或DA能末梢之间的突触联系；用脑片膜片钳记录VLO微小兴奋性突触后电流(mEPSC)，观察D1 受体激动剂、拮抗剂对mEPSC的影响及可能的胞内信号转导机制；记录VLO内GABA能微小抑制性突触后电流 (mIPSC)，观察D2受体激动剂、拮抗剂对mIPSC的影响及可能的胞内信号转导机制。为证明D1受体可能直接激活VLO投射神经元和D2受体通过抑制GABA能神经元，间接激活投射神经元，进而激活下行抗伤害通路，产生镇痛的假设提供形态学与机能学证据，具有重要的理论意义和潜在的应用前景。
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数据更新时间：2023-05-31
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