ASB3负反馈调控流感病毒天然免疫应答的机制

Influenza (Flu) is an acute respiratory disease caused by influenza virus infection. When the influenza virus infects host cells, the innate immune system of the host cells will sense the viral components, stimulate a series of signal transduction pathways, and ultimately induce the expression of type I interferon which play an important role in virus clearence. It is of great significance to understand the regulation mechanism of host innate immunity against viral infection. By screening the gene expression profile, we found ASB3 was up-regulated in the process of influenza virus infection. Preliminary functional studies have shown that ASB3 is able to bind and inhibit IRF3, negatively regulates the transcription of type I interferon and promotes viral replication. Therefore, ASB3 is likely to act as a new antiviral immune regulatory factor. This project is plan to further study the inhibitory mechanism of innate immune signaling pathway by ASB3 during influenza virus infection, and to understand the function of ASB3 in virus-host interaction. Our research thus would provide a theoretical basis for the development of new strategies to control virus infection.

流行性感冒（简称流感）是由流感病毒感染引起的急性呼吸道疾病，具有传染性强、传播速度快等特点。当流感病毒感染宿主细胞后，宿主细胞的天然免疫系统会识别病毒成分，并激发一系列的信号转导途径，最终诱导I型干扰素的表达，发挥抗病毒功能。探讨宿主细胞抗病毒天然免疫的调控机理，对于全面认识病毒感染的发生、进展和转归过程具有重要意义。通过前期的表达谱基因芯片筛选，我们发现了一个在流感病毒感染过程中上调表达的基因ASB3。初步的功能研究显示，ASB3能够结合并抑制IRF3，负调控I型干扰素转录，促进病毒复制。因此，ASB3很有可能是一个新的抗病毒免疫调控因子。本项目拟研究流感病毒感染过程中ASB3上调表达及其抑制天然免疫信号通路的机制，揭示ASB3在病毒与宿主细胞相互作用中的新功能，为深入认识病毒感染过程及开发抗病毒新策略提供理论基础。

流行性感冒（简称流感）是由流感病毒感染引起的急性呼吸道疾病，具有传染性强、传播速度快等特点。当流感病毒感染宿主细胞后，宿主细胞的天然免疫系统会识别病毒成分，并激发一系列的信号转导途径，最终诱导I型干扰素的表达，发挥抗病毒功能。探讨宿主细胞抗病毒天然免疫的调控机理，对于全面认识病毒感染的发生、进展和转归过程具有重要意义。通过前期的表达谱基因芯片筛选，我们发现了一个在流感病毒感染过程中上调表达的基因ASB3。初步的功能研究显示，ASB3能够结合并抑制IRF3，负调控I型干扰素转录，促进病毒复制。因此，ASB3很有可能是一个新的抗病毒免疫调控因子。本项目拟研究流感病毒感染过程中ASB3上调表达及其抑制天然免疫信号通路的机制，揭示ASB3在病毒与宿主细胞相互作用中的新功能，为深入认识病毒感染过程及开发抗病毒新策略提供理论基础。