乌头类有毒中药炮制配伍减毒机理的体外模型研究
基本信息
结项摘要
本项研究拟以乌头类有毒中药附子、川乌及草乌为研究对象，采用软电离质谱技术和液相色谱-质谱联机技术为研究手段,利用Caco-2单细胞层模型，针对乌头类有毒中药在炮制、配伍前后，乌头碱类生物碱在小肠中吸收转运及代谢机理进行系统地研究，考察其炮制、配伍过程对乌头碱类生物碱吸收转运的影响规律，阐明乌头类有毒中药在炮制、配伍和吸收转运前后乌头碱类生物碱的变化规律，揭示乌头类有毒中药炮制、配伍减毒增效机理及化学物质基础，建立有毒中药炮制、配伍减毒增效机理的体外模型研究方法和质谱分析方法。
项目摘要
项目成果
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数据更新时间：2023-05-31
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