微生态周期切换式厌氧系统对头孢曲松的生物协同控制机制

The proposed project is based on understanding the feasibility of pharmaceutical wastewater containing ceftriaxone to be treated in an anaerobic system with a period-switching miccrobe ecology, targeting the production needs of antibiotics market and the requists of economical and applicable biological wastewater treatment process from pharmaceutical industrial enterprises. The biodegradation pathway and intermediate of ceftriaxone and the positive or negtive influence of the period-switching miccrobe ecology on them are unveiled. The dynamic succession law of microbial community structures transferred by the period-switching miccrobe ecology in each compartment is investigated in order to get the optimal microbial community structures to enhance the removal performance of ceftriaxone and its biodegradation products. Control means of cooperative synergy between hydraulic property and ecological factors, which optimizes operation manner of the system to achieve optimal performance is explored. The optimizing system of bio-cooperative control mechanism for ceftriaxone-containing pharmaceutical wastewater treatment in an anaerobic system with a period-switching miccrobe ecology is formed. A new anaerobic biological wastewater treatment technology and its theoretical bases and technological platform in basic application studies is provided to the water pollution control and management of antibiotics pharmaceutical industrial enterprises in practical engineering application.

课题针对市场对抗生素的生产需求，以及制药工业企业对经济适用的废水生物处理工艺的生产需要，基于微生态周期切换式厌氧系统处理头孢曲松制药废水的可行性展开研究，揭示头孢曲松的降解途径与中间产物及其所受微生态周期切换的正向或负向影响，探明系统各隔室内微生物群落结构随周期切换的微生态而迁移的动态演替规律，获得系统各隔室内强化头孢曲松及其降解产物去除效能的最佳微生物群落结构，探求水力学特性及各生态因子的耦合协同作用对优化系统运行模式以达到最佳效能的控制方法，构建微生态周期切换式厌氧系统处理头孢曲松制药废水生物协同控制机制优化体系。为抗生素制药工业企业水污染防治和管理的实际工程应用提供新型厌氧生物处理技术及其应用基础研究理论依据与技术平台。

基于微生态周期切换式厌氧系统处理头孢曲松制药废水的可行性展开研究，揭示头孢曲松的降解途径与中间产物及其所受微生态周期切换的正向或负向影响，探明系统各隔室内微生物群落结构随周期切换的微生态而迁移的动态演替规律，获得系统各隔室内强化头孢曲松及其降解产物去除效能的最佳微生物群落结构，探求水力学特性及各生态因子的耦合协同作用对优化系统运行模式以达到最佳效能的控制方法，构建微生态周期切换式厌氧系统处理头孢曲松制药废水生物协同控制机制优化体系。为制药工业企业水污染防治和管理的实际工程应用提供新型厌氧生物处理技术及其应用基础研究理论依据与技术平台。