中国棉铃虫单核衣壳核多角体病毒膜融合蛋白的结构和功能研究
基本信息
结项摘要
本研究以中国棉铃虫单核衣壳核多角体病毒（HaSNPV）膜融合蛋白（F蛋白）HA133为研究对象,深入研究杆状病毒NPV组II膜融合蛋白的结构和功能。重点研究：1.该蛋白的主要翻译后修饰特征；2.通过对推测的核心结构-三个7氨基酸重复区（HR）的原核表达、晶体生成和结构分析，对HaSNPV的核心结构进行结构生物学解析; 3.通过开展三个HR相应肽段及相应抗体对病毒感染的抑制研究, 揭示HR区在膜融合
项目摘要
项目成果
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数据更新时间：2023-05-31
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