SOX1参与副肿瘤性抗GABABR脑炎抗原表达机制的研究

Autoimmune encephalitis plays a key role of the encephalitis with a high mobidity and misdiagnosis. It is a curable disease, but the mechanism remains unclear now. It has been studied relatively more for anti-NMDAR encephalitis, but the study of anti-GABABR encephalitis is not intensive enough. Our previous studies outcome of the former National Natural Science Foundation and research showed that GABABR antibody is most likely the diagnosis marker of paraneoplastic neurological syndromes, and SOX1 may be an important marker of anti-GABABR encephalitis. We speculated that SOX1 may be a therapeutic target of anti-GABABR encephalitis and paraneoplastic neurological syndromes. We will investigate the relations of SOX1, anti-GABABR encephalitis and paraneoplastic neurological syndromes by chromatin immunoprecipitation, flow cytometry and immunofluorescence. The study findings will provide the new ideas for early diagnosis and treatment of autoimmune encephalitis.

自身免疫性脑炎是一种发病率高、误诊率高、机制未明的可治性疾病。迄今对抗NMDAR脑炎的研究受到更多关注，而对抗GABABR脑炎知之甚少。已知自身免疫性脑炎与神经系统副肿瘤综合征密切相关。我们前期国家自然基金成果及相关工作发现：GABABR抗体极可能是神经系统副肿瘤综合征的诊断标记物，而SOX1又可能是抗GABABR脑炎重要标记物。由此推测，SOX1极可能是治疗抗GABABR脑炎及神经系统副肿瘤综合征的重要靶点。本课题拟采用染色质免疫共沉淀，流式细胞术和免疫荧光等技术探讨SOX1、抗GABABR脑炎和神经系统副肿瘤综合征之间的相互作用关系，这将为我们早期诊断和应对自身免疫性脑炎的治疗提供新的思路。

自身免疫性脑炎是一种发病率高、误诊率高、机制未明的可治性疾病。迄今对抗NMDA R脑炎的研究受到更多关注，而对抗GABABR脑炎知之甚少。已知自身免疫性脑炎与神经系 统副肿瘤综合征密切相关。项目研究中研究证实了SOX1可结合于GABABR的启动子区，调控GABABR的转录和表达，可能参与抗GABABR脑炎的发生发展。SOX1可能成为抗GABABR脑炎重要标记物及治疗抗GABABR脑炎及PNS的靶点。这将为我们早期诊断和应对自身免疫性脑炎提供新思路。