基于多禁带光子晶体微球构建"Array on One Particle"传感体系

Integrating different sensing modes into one single sensor unit to realize accurate discrimination and information transmission for complex component systems is of great significance to develop new sensor, but represents big challenge. In this project, a new strategy for efficiently constructing such sensor array with specific recognition and cross-reactive sensor array analysis based on single photonic crystal sphere which has multi-band gap and structure is proposed. The extraordinary multiple intermolecular interactions involved in the ionic liquid units make one single sphere differentially interact with broader classes of analytes, thus generating response patterns with remarkable diversity. Moreover, the poly(ionic liquid) photonic sphere with multi-band gap and structure is designable and customizable through post modification, and target-oriented multi-analyte sensing can also be conveniently realized using a selective receptor species, which provide multidimensional sensing modes and signal channels on only one sphere sensor element. The implementation of this project will allow for the establishment of a new method for conveniently constructing single sensor unit with multi-sensing modes and multichannel for multianalyte detection and discrimination with a series of advantages, such as great flexibility and extendibility, customizable task-specific performance, and a broad application range.

将不同分子识别模式和信号通道集成于单个传感单元，实现对多组分体系高效的检测和分析对传感器件的发展和应用具有十分重要的意义。本项目基于已取得的初步成果，构建具有特异性识别与交互响应阵列识别相结合的多重识别模式，多信号通道的单光子晶体微球，实现“Array on One Particle"传感体系。聚离子液体与客体分子丰富的相互作用有助于实现基于单微球的交互响应传感与识别，通过可控刻蚀与逐层修饰手段，对微球的结构、功能以及信号通道进行灵活的设计与调制，最终构筑在单个光子晶体微球上能同时实现对一般多组分体系的广普性交互响应阵列识别和对结构、性质相近分子混合体系的特异性识别的多重识别模式和多信号通道的传感单元及阵列。本项目的设立和开展，有望发展出一种兼具灵活性和拓展性等优点的构筑多信号通道光子晶体微球传感体系的新策略，实现一类基于单个光子晶体微球的特异性识别和多分析物的交互响应阵列识别体系。

将不同分子识别模式和信号通道集成于单个传感单元，实现对多组分体系高效的检测和分析对传感器件的发展和应用具有十分重要的意义。本项目基于已取得的初步成果，构建具有特异性识别与交互响应阵列识别相结合的多重识别模式，多信号通道的单光子晶体微球，实现“Array on One Particle"传感体系。聚离子液体与客体分子丰富的相互作用有助于实现基于单微球的交互响应传感与识别，通过可控刻蚀与逐层修饰手段，对微球的结构、功能以及信号通道进行灵活的设计与调制，最终构筑在单个光子晶体微球上能同时实现对一般多组分体系的广普性交互响应阵列识别和对结构、性质相近分子混合体系（毒品）的特异性识别的多重识别模式和多信号通道的传感单元及阵列。针对现场条件下苯丙胺类化合物各对映体，按照检测单元-检测芯片三者逐步递进，最终得到多信号通道的单光子晶体微流控检测芯片。本项目的设立和开展，有望发展出一种兼具灵活性和拓展性等优点的构筑多信号通道光子晶体微球传感体系的新策略，实现一类基于单个光子晶体微球的特异性识别和多分析物的交互响应阵列识别体系。