稀土基纳米探针的合成、毒理评价及其于多模式成像方面的应用

Because of their unique electric, magnetic, and optical properties, multifunctional nanomaterials have been proved promising in biomedicine. In particular, intense research activities have concentrated on the application of nano-sized contrast agents in multi-modal imaging. In this project, a series of novel lanthanide-based nanoparticulate contrast agents will be designed and constructed via green and facile methods instead of previously reported complicated processes and time-consuming experiments. More importantly, all the raw materials used in this project are easily available, which motives the large-scale preparation of these nanoprobes. In addition, long-term toxicity, bio-distribution, and clearance routes of these well-prepared nanoprobes will be discussed and evaluated in detail. Several high-performance and low-toxicity nanoprobes will be selected as nanoparticulate contrast agents for single-modal imaging, multi-modal imaging, and targeted imaging both in vitro and in vivo. Based on our optimized synthesis routes, controlled surface modification, and detailed toxicity investigations, above results of the presented project will thereby promise the applications of these materials as nano-sized contrast agents.

多功能纳米材料因其独特的电学、磁学及光学性质于生物医学领域有着广泛的应用。近年来，纳米造影剂用于多模式成像的应用引起了科学家的极度关注。本项目中，我们拟设计并合成一系列新型的稀土基功能化纳米造影剂，相比以往复杂的合成路径及耗时的实验步骤，本项目的合成技术更为绿色、简便。更重要的是，本项目所提及的所有原材料均容易获得且廉价，进而推动了大规模制备纳米造影剂的可行性。此外，我们对理化性质优越的纳米探针进行详细的长时毒理研究、生物分布分析及代谢途径考察。几种高性能、低毒性的纳米造影剂将用于体外及活体层面的单模式成像、多模式成像及靶向成像体系。基于项目中优化的合成路径、可控的表面修饰方法及细致的毒性考察，本项目所提供的结论为纳米造影剂的应用提供了更深远的契机。

伴随着纳米科技与生物工程的迅猛发展，以稀土基微纳生物材料为代表的一系列材料在临床疾病的诊断、预后和治疗方面突现出显著的应用价值。本项目理性的设计并合成了一系列新型微纳生物材料，从体内外层面系统考察了其生物兼容性和长时毒性，因其自身特性将其针对性的应用于不同的生物医学领域。项目不仅将稀土基微纳生物材料作为新型多模态成像试剂，而且还将所构筑的多种新型微纳生物材料应用于生殖控制，细胞氧化还原平衡调节，抗肿瘤/抗菌治疗，纳米疫苗等前沿生物医学领域。本项目所取得的系列成果将为微纳生物材料的可控合成及生物医学应用提供更深远的契机。