EGFR激活STAT3信号转导途径在维吾尔族宫颈癌发生发展中恶性表型及调控机制研究

In the south of Xinjiang Uighur women with cervical cancer mortality rate ranking first in the national minority, research shows that EGFR mediated signaling pathways play an important role in the development in a variety of tumors and the EGFR target therapy is considered to be one of the most hope in advanced cervical cancer patients. Previous research found that among Uygur women in lower HPV infection rate, but has a high incidence of cervical cancer, this study to EGFR mediated STAT3 signaling pathway as the center, through in tumor models and vitro and transplantation human tissue specimens by EGFR ligand blocking, inhibited the target to drug molecules, RNA interference, gene expression,real-time PCR technology of EGFR mediated PKM2/STAT3 signaling pathway in the pathogenesis of cervical cancer, discuss these factors and cervical cancer.occurrence and changes and ethnic differences in outcome. To investigate the Uyghur medicine camel thorn extract target to the feasibility and curative effect of treatment of cervical cancer, and provide new ideas and theoretical basis for the pathogenesis of cervical cancer research and prevention.

新疆南疆地区维吾尔族妇女宫颈癌病死率在全国少数民族中居第一位，研究显示,EGFR介导的信号通路在多种肿瘤的发生发展中起重要作用，以EGFR为靶点的治疗被认为是最有希望的中晚期宫颈癌治疗方法之一。前期研究发现维吾尔族妇女人群在较低的HPV感染率下，却具有很高的宫颈癌发病率，本研究以EGFR介导的STAT3信号通路为中心，通过体外细胞实验、移植瘤模型及人组织标本，采用EGFR配体阻断、靶向分子药物抑制、RNA干扰、基因过表达、Realtime PCR等技术研究EGFR介导的PKM2/STAT3信号通路在宫颈癌发病机制中的作用，探讨这些因子与宫颈癌发生和转归变化的关系及民族差异。探讨维药骆驼刺提取物靶向治疗宫颈癌的可行性及疗效，进而为宫颈癌的发病机制研究及防治提供新思路和理论依据。

新疆南疆地区维吾尔族妇女宫颈癌病死率在全国少数民族中居第一位，研究显示,EGFR介导的信号通路在多种肿瘤的发生发展中起重要作用，以EGFR为靶点的治疗被认为是最有希望的中晚期宫颈癌治疗方法之一。前期研究发现维吾尔族妇女人群在较低的HPV感染率下，却具有很高的宫颈癌发病率，本研究以EGFR介导的STAT3信号通路为中心，通过体外细胞实验、移植瘤模型及人组织标本，采用EGFR配体阻断、靶向分子药物抑制、RNA干扰、基因过表达、Realtime PCR等技术研究EGFR介导的PKM2/STAT3信号通路在宫颈癌发病机制中的作用，探讨这些因子与宫颈癌发生和转归变化的关系及民族差异。探讨维药骆驼刺提取物靶向治疗宫颈癌的可行性及疗效，进而为宫颈癌的发病机制研究及防治提供新思路和理论依据。