用于高效跨越脑胶质瘤血脑屏障的新型多功能纳米诊疗剂的实验研究

With the rapid progress in developing nano-theranostics across the blood brain barrier(BBB), the synthesis of a BBB acrossed theranostics with capabilities like multi-mode imaging,targeted delivery and radiotherapy enhancement, has attracted increasing attention in nano-biotechnology research, and will have promising prospect clinically and fundamentally for the treatment of brain diseases in the future. Here, we aim to develop a glioma targeted theranostics across BBB based on our newly proposed "module-assembly" technique. By "module-selection" and "module-assembly", greatly enhanced performance will be achieved after wise integration of upconversion nanoparticles (optical/magnetic imaging), azobenzene molecules (photosensitizers), Angiopep-2 (targeting ligands), Cisplatine（drugs and radiosensitizers）resulting in BBB acrossed，tumor targeted bimodal imaging and synergistic therapy nanomedicine. Systematic structure design, characterizations and in vivo imaging and therapy demonstrations will be carried out for evaluating its potential in early diagnosis and therapy of future cancer. Our study on design and synthesis of theranostic nanomedicines will shed new light on the novel medical treatment in the coming future.

跨越血脑屏障纳米诊疗剂是纳米生物技术研究的一个热点，对未来脑胶质瘤等重大脑部疾病的诊断和治疗有着重要的研究意义和应用前景。本项目将"模块协同"设计理念引入基于高效跨越血脑屏障的纳米诊疗剂的结构设计中，通过巧妙地模块选择、设计与高效的复合，实现结构整体性能的提升。在此基础上，通过抗癌药物和光敏剂偶氮苯分子的引入，以及具有双靶向功能的Angiopep-2多肽的链接，最终形成集高效跨越血脑屏障、多模态影像诊断、近红外光控药物释放、放疗增敏等多功能于一体的新型多功能纳米诊疗剂。系统研究该多功能纳米诊疗剂在体外和体内的生物学效应，评估其用于脑胶质瘤高效诊治的应用潜力，为探索人类重大脑部疾病（如脑胶质瘤、阿尔茨海默症、帕金森症等）的高效早期诊断兼原位治疗等新型医疗技术提供借鉴性研究思路和方法。

跨越血脑屏障纳米诊疗剂是纳米生物技术研究的一个热点，对未来脑胶质瘤等重大脑部疾病的诊断和治疗有着重要的研究意义和应用前景。本项目将“模块协同”设计理念引入基于高效跨越血脑屏障的纳米诊疗剂的结构设计中，通过巧妙地模块选择、设计与高效的复合，实现结构整体性能的提升。在此基础上，通过抗癌药物和光敏剂分子的引入，以及具有双靶向功能的Angiopep-2多肽的链接，最终形成集高效跨越血脑屏障、多模态影像诊断、近红外光控药物释放、放疗增敏等多功能于一体的新型多功能纳米诊疗剂。系统l研究了该多功能纳米诊疗剂在体外和体内的生物学效应，评估其用于脑胶质瘤高效诊治的应用潜力，为探索脑胶质瘤的高效早期诊断兼原位治疗等新型医疗技术提供借鉴性研究思路和方法。